Abstract: Ophthalmologic manifestations of BD, especially posterior uveitis and retinal vasculitis are resistant to most treatments, leading to sever loss of vision. Cytotoxic drugs, especially chlorambucil and cyclophosphamide (CP) are effective in some patients. In a preliminary report to the XI EULAR Congress of Rheumatology we demonstrated the efficacy of PTCP in these lesions. PTCP was performed by perfusion of 1 g. CP per square meter of body surface in 500 ml of normal saline. PTCP was repeated every months after a new evaluation of the patient. 102 patients are actually under this treatment. 67 of them had received 4 pulses or more (a total of 438 pulses). Statistical analysis was done by the Student paired t test. The mean visual acuity improved from 3.7 to 4.3 (t=3.213, p<0.005). The same improvement was observed with anterior uveitis (t=4.399, p<0.001),and with posterior uveitis (t=6.475, p<0.0005). Retinitis also improved (t=2.915, p<0.01). Side effects were minor. Full data will be discussed.