Abstract: Porpose: To determine the risk factors in the prognosis and the visual outcome of the disease. Methods: This is a retrospective study of 361 patients, having Behcet’s disease and treated by immunosuppressives and steroids, followed-up at Shariatti Hospital (mean duration of follow-up was 2.27 years). The ocular examinations at the first and last visit are recorded and compared. Results: Vision First visit % of eyes Last visit % of eyes NLP 2.98% 6.18% LP-HM 6.67 7.18 0.7-1.0 E 48.09 55.03 The retinal vasculitis was the major cause of blindness and the risk factors were the following: Lesion First visit % of eyes Last visit % of eyes Arterial necrosis 2.77 5.26 Venous necrosis 2.2 5.1 Macular scar 5.5 9.0 Optic atrophy 4.6 6.8 The arterial necrosis was more frequent in the male populatin (29 male, 9 famale) p<0.01. Conclusion: Vasculitis was the major cause of blindness and was more frequent in the male populations. Intensive treatment should be undertaken early in the course of the disease.