Abstract: The aim of this study is to propose a scoring system to determine the activity of the eyes, and to evaluate our medications in the treatment of ocular inflammation and vasculitis in Behect's disease (BD). Eleven activity and 5 chronicity (constant) parameters are scored from zero to 4 to consider the condition of each eye in Oculo-Behcet's disease. Both parameters are considered in our therapeutic scoring. The activity variables are: Episcleritis and/or ...
Abstract: Introduction: There are several reports of good effects of Cyclosporine A (CsA) in the treatment of Behcet's disease (BD). We studied the long term effect of CsA in prospective open clinical trial on posterior uveitis (PU) and retinal vasculitis (RV) of BD. Materials & Methods: Twenty three patients with PU and/or RV diagnosed as BD (according to the Iran and to the Japan criteria) were selected. Initially CsA 5 mg/Kg/day orally ...
Abstract: Introduction: there are several reports of good effects of Cyclosporine A (Cs A) in the treatment of Behcet's disease (BD). We studied the long term effect, of A Cs A in a prospective open clinical trial on posterior uveitis (PU) and retinal vasculitis (RV) of BD. Materials & Methods: Twenty three patients with PU and / or RV diagnose as BD (according to the Iran and to the Japan criteria) ...
Abstract: The outcome of ocular manifestations of Behcet’s Disease remains uncertain and unpredictable despite cytotxic drugs. One of our recent studies, presented to the 1995 Korean Rheumatology Annual Meeting, showed that one third of patients were None Responders, regardless of what treatment used. This study was designed to search for factors predicting the final outcome at the beginning of the treatment. Patients having more than one year of treatment were selected ...
Abstract: Behcet’s Unite, Shariati Hospital the aim to propose a scoring system for the treatment of the ocular inflammation one vasculitis by our medications and to evaluate the state of the activity of the eye. Eleven activity and five chronicity (constant) parameters are scored from zero to four to consider the condition of each eye. The activity variables are: episcleritis &/or scleritis, anterior uveitis, hyalites, IMU, central periphlebitis &/or thrombosis, central periartertis, peripheral ...
Abstract: Introduction: Opthalmologic manifestations are the major cause of morbidity in Behcet’s Disease. If not treated, they usually progress toward sever loss of vision or blindness. Cytotoxic drugs are the main therapeutic agents. Materials & Methods: In an open, non randomized, control study, pulse cyclophosphamide (PCP), low dose pulse cyclophosphamide (LDP), weakly methtrexate (MTX), chlorambucil (CHL), oral cyclophosphamide (OCP), and cyclosporine A (CYA) were used in a standard protocol for 778 patients. ...
Abstract: There are only two nationwide surveys of Behcet's Disease (BD) in the world, one from Japan and one from Iran. The comparison of the two surveys is interesting because the populations are racially different, although they share same genetic background via the invasion of Iran by Turk tribes (from the northem part of China) in the 10 th and 13 th century. The annual incidence of BD in Iran is 350 ...
Abstract: Porpose: To determine the risk factors in the prognosis and the visual outcome of the disease. Methods: This is a retrospective study of 361 patients, having Behcet’s disease and treated by immunosuppressives and steroids, followed-up at Shariatti Hospital (mean duration of follow-up was 2.27 years). The ocular examinations at the first and last visit are recorded and compared. Results: Vision ...
Abstract: Results of PCP are well known in lupus nephritis. We present here it’s outcome in patients with WHO type IV lupus nephritis, treated before the occurrence of renal failure. Patients having a follow up of more than 36 months were selected for this study. 29 patients fulfilled the selection criteria. Proteinuria, hematuria, leucocyturia, cast, BUN, creatinine and blood pressure were measured before PCP and after each one. The first and ...
Abstract: In a study on 391 cases of BD presented to the EULAR Congress in 1987 we demonstrated that the following symptoms were seen more frequently in patients with positive pathergy phenomenon: oral aphthosis as the initial manifestation of the disease, genital ulcerations, pseudofolliculitis, and arthralgia. The following symptoms, on the contrary were seen less frequently: oral aphthosis, ankylosing spondylitis. It was interesting to look after those findings, 6 years later, in ...