Abstract: Introduction: Ocular lesions are the major cause of morbidity in Behcet’s Disease. If not treated they usually progress toward severe loss of vision or blindness. Cytotoxic drugs are the main therapeutic arsenal used for this condition. Materials & Methods: In an open, non randomized control study, pulse Cyclophosphamide (PCP), low dose pulse cyclophosphamide (LDP), oral cyclophosphamide (OCP), weakly methotrexate (MTX), chlorambucil (CHL), and cyclosporine A (CYA) were used in a standard ...
Abstract: Neuropsychiatric manifestations of SLE are frequent and usually serious, convulsion is one of the most important and hazardous symptoms of CNS-LUPUS. Because there are many differences in clinical manifestations frequency and severity of organ systems involvement, and cause of death in patients with SLE (in Iran and other countries) an analytic retrospective case-control study was carried out to evaluate the frequency of convulsion in relation with age and sex distribution, ...
Abstract: Anti-neutrophil cytoplasrnic autoantibodies (ANCA) were first described in patients with necrotizing glomerulonephritis. The original observation passed virtually unnoticed until an association was found between ANCA and active Wegener's granulomatosis. Since then, tremendous progress has been made in elucidating the association between ANCA subtypes and clinicopathologic syndromes, and in considering potential pathogenic role of ANCA in vascular inflammation. The gold standard method for ANCA detection rests with indirect immunofluorescence (IIF) microscopy. ...
Abstract: Anti-cardiolipin antibodies (ACA) occur in patients with SLE, lupus-like illness and with some other illnesses, such as malignancy, syphilis and among healthy elderly. We found that the prevalence of IgG and IgM ACA isotopes in 147 Iranian SLE patients was 49.7% for IgG and 5.6% for IgM. In addition, some SLE and non-SLE patients from other centers were studied: the prevalence of ACA-IgG in SLE patients from Mashad was 54%; ...
Abstract: There are only two nationwide surveys of Behcet's Disease (BD) in the world, one from Japan and one from Iran. The comparison of the two surveys is interesting because the populations are racially different, although they share same genetic background via the invasion of Iran by Turk tribes (from the northem part of China) in the 10 th and 13 th century. The annual incidence of BD in Iran is 350 ...
Abstract: In this research we have studied the peripheral blood neutrophils phagocytosis and serum opsonic capacity by luminal excited chemiluminescence method. in 73 cases, who, evaluated in this research, none of them received any therapeutic drugs. All of cases, consists of 34 normal subject (female=l9, male=l5) and 18 patient control (included RA= 5, JRA=1, Polymyositis = 1, Behcet disease = 2, AS =3, Vascuiitis = 3 and scleroderma = 3) and 21 ...
Abstract: Introduction: BMD varies in different countries due to different genetic and environmental factors, It is necessary to determine BMD in normal population of Iran. This study was designed by the Rheumatology Research Center to fulfill this task. It was achieved by a grant from the Deputy Ministry for Research, the Ministry of Health, Treatment and Medical Education. Materials and methods: 280 normal Iranians were selected randomly from staffs of Shariati Hospital ...
Abstract: In order to study a possible relation between mechanical bone pains and the BMD, 1335 patients were analyzed as every consecutive patient. The BMD was measured in a cohort study on 5927 patients referred for various reasons to the Rheumatology Research Center, Osteoporosis Unit. The BMD was measured by Dual Energy X-rays Absorptiometry (DEXA) on the lumbar spine (L1-L4) and the femoral neck. Patients having an inflammatory disease such as ...
Abstract: Menopause is one of the most important accelerating factors of bone loss in women. This study was designed to evaluate the effects of the age of menopause on BMD in Iranian women. The women referred for Bone Densitometry who were menopaused and did not have hysterectomy before their menopause were selected as every consecutive patient. Those who had any other risk factor for osteoporosis were excluded. The patients were divided ...
Abstract: The concept that rheumatoid arthritis (RA) is an autoimmune disease is supported by variety of autoantibodies in patient's serum. The most important of these are rheumatoid factors (RFs), antibodies that react with the patient's own Ig. It has been suggested that IgM-RF plays a role in disease pathogenesis. The main source of IgM-RF are B cells that express the pan T-cell marker, CDS: We conducted this study to test the ...