Abstract: We have reported a 100% association of ocular type of BD with B5 cluster antigens. The HLA results of non ocular type shows respectively 30% and 40% of association with B5 and B5 cluster antigens. These results indicate that B5 cluster antigens are decreased in non ocular patients compared to 62% of normal population. Considering the etiologic fraction for B5 cluster in ocular type patients which was at its maximum ...
Abstract: Behcet's Disease (BD) has been found to be related to the first class HLA antigens, the B5. In Iran, B5 is present in 64% of BD patients versus 34% in normal population. The relative risk is 3.33. Uveitis has been demonstrated to be related to the presence of B5. in our study the posterior uveitis was present in 59% of patients with B5 versus 48% without it (p
Abstract: The association of B5 and uveitis has been previously demonstrated. 37 patients with ocular form were studied for HLA, ABC and DR antigens, with a large panel of antisera (A.O.H.W.C panel sera). Results are: Antigen Control Patient Relative R. ...
Abstract: Patients were divided in 2 groups of positive and negative pathergy test. 57 parameters including symptoms and paraclinical tests were analyzed seperately in the 2 groups and then compared to each other by the chi sqaure test (the fourfold table method). The following symptoms were seen more frequently in patients with a positive pathergy test: oral aphthosis in the beginning of the disease (p
Abstract: The skin hyper reactivity (SHR) as detected by the pathergy test is a common feature of Behcet's Disease (BD) in Middle East Countries and in Japan, but not in Western Countries. Yazici et al showed it's sensitivity and it's specificity. As the SHR in pathergy test is revealed by a pseudo folliculitis, it may have the same significance as the spontaneous pseudo folliculitis (PF) of BD. Thus if a patient ...
Abstract: In 225 patients with definit Behcet's Disease I5 clinical and 5 paraclinical parameters (CBC,ESR, urinalysis,B5,Pathergy test) were statistically analyzed. The chi-square test (X2) was used for the analysis of difference and P values smaller than 0.05 were accepted as a significative difference between male and female patients. Ophthalmologic manifestations were more frequent in males (80%) than females (63%),X2=7.91,0.01> P> 0.001.The difference concern specially the uveitis (73% males,55% females,X2=7.65,0.01>P>0.001). In osteoarticular ...
Abstract: 35 patients with the “complet form“ of Behcet’s disease, according to the criteria of Behcet’s Disease Research Committee of Japan were selected for study. The choice of complet forms make possible to have a more homogenous group of patients to evaluate the effect of levamisole on the major symptoms of the disease. The patients were treated with levamisole at least for 3 to 6 months, they had no cytotoxic ...
Abstract: INTROUCTION: Ophthalmologic manifestations are the major cause of morbidity in Behcet's Disease. If not treated, they usually progress toward sever loss of vision or blindness. Cytotoxic drugs are the main therapeutic agents. MATERIALS & METHOD: In an open, non randomized, control study, Pulse Cyclophosphamide (PCP), low dose pulse cyclophosphamide (LDP), weakly methotrexate (MTX), chlorambucil (CHL), oral cyclophosphamide (OCP), and cyclosporine A (CYA) were used in a standard protocol for 778 ...